The trial duration of more than 6 years, the high rates of follow-up and treatment adherence, the large number of cardiovascular outcomes, and the prospective collection and adjudication of the outcomes ensured sufficient power to detect a clinically essential short-term or medium-term cardiovascular effect. In addition, the prospective assortment of data pertaining to hypoglycemia, weight gain, and cancers ensured that potential harms were detected and quantified. Limitations of the study include the reality that metformin was ultimately utilized by 47 percent of the insulin-glargine group. Evidence that metformin is cardioprotective14,15,28 raises the possibility that any cardiovascular damage of insulin may have been mitigated by metformin.Here’s how it works. The patient is certainly injected with a modified virus that contains PSA . When your body’s immune system encounters this virus it learns that virus is harmful and should be attacked. Since this virus offers PSA features in it researchers wish that the immune system may also attack prostate cancer cells which contain PSA, strategically destroying prostate malignancy cells thus. This form of treatment is indeed promising because it could prove to be very effective with hardly any side effects.