Alkermes initiates ALKS 37 phase 2b research in opioid-induced constipation Alkermes plc today announced the initiation of a phase 2b study of ALKS 37, an orally active, peripherally restricted opioid antagonist for the treating opioid-induced constipation silagra . This multicenter, randomized, double-blind, placebo-controlled, fixed-dose research is designed to assess the basic safety and efficacy of daily administration of a 100 mg dose of ALKS 37 versus placebo for 12 weeks in approximately 80 individuals with OIC. The full total results of the phase 2b study, along with those from the dose-ranging, four-week phase 2b study initiated previously this full year, are expected to be part of the End-of-Phase 2 submission package to the U.S.
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