C – Line E. Horst Vogel, Sidney A pde5 inhibitor . Sami Damak , and Johannes le Coutre?Divalent salts of iron, copper and magnesium, metallic taste, but also evoke different sensations, including astringent, salty and bitter. Riera et al. Investigate which receptors mediate these tastes by taste tests in wild-type and knockout mice. Mice chose water with low concentrations of zinc and iron sulfate over distilled water, but avoided high concentrations of these salts. Mice copper and magnesium sulfate avoided at all concentrations. Attractive properties of zinc and iron were probably mediated by the transient receptor potential protein TRPM5, which contributes sweet and bitter taste and T1R3, a subunit of sweet and umami receptors: knock out of these proteins eliminated preferences and increased aversion to zinc and iron. In contrast, knockout of TRPM5 reluctance reduced with magnesium and copper. Knockout of TRPV1 reduced aversion to iron and copper salts. Aversion to divalent salts was never eliminated, but suggesting that other proteins help mediate their tastes. Disturbance of EGR2 – NAB2 Interaction Reduces myelination.
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