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Background on the technical approachMany-to clinically relevant interactions by inhibition and / or induction of a CYP enzyme such as 3A4 connected. Change in CYP activities can profoundly affect therapeutic efficacy and lead to life-threatening toxicity. Examples of costly high-profile drug withdrawals due to CYP – related DDIs include antihistamines terfenadine and astemizole, the antihypertensive mibefradil and statins such as cerivastatin. A validated, simple, cost will be useful for in vivo CYP assay profiling drug metabolism prior to performing expensive mammalian testing. Owing to their physiological and genetic similarity to humans have shown that zebrafish efficient one, high throughputmal model for assessing drug metabolism and drug safety.

Only a little more than half the 18 million Americans did diagnosed with diabetes their blood sugar, cholesterol and blood pressure under optimum control in the year 2006, of to the latest Messaging and Facts in the Agency Healthcare Research and Value.