Hemagglutinin helps the door to the cell, thus infecting the virus the first step in this process to the binding of the hemagglutinin. Sialic acid containing molecules in the cell surface, there are basically two ways sialic acids with molecules of the cell surface associated – one is through an alpha-2,6 – bond and another by an alpha-2,3 – binding http://suhagra4ed.com/erectile-dysfunction-treatment.html . Andtinins from avian influenza virus prefer binding to alpha 2-3 sialic acids, while hemagglutinins from human influenza viruses prefer binding to alpha 2-6 sialic acids abundant in the abundant in the upper respiratory tract of humans. Be for a bird flu virus is able to jump to humans and pandemic was pandemic was hypothesized that the hemagglutinin to mutate and change its binding preference alpha2-3 to alpha2-6 sialic acids have.
In this study, researchers used ferrets as an animal model of human influenza virus infection by the presence of alpha2-6 sialic acids in the respiratory tract of ferrets, similar to the human scenario. Groups of ferrets three types three types of influenza viruses, two.
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