Abstract: Corin is a membrane-bound protease that regulates blood circulation pressure by activating the natriuretic peptides. CORIN variants have been associated with hypertension and cardiovascular disease in African Americans. In this scholarly study, we conducted targeted exome sequencing and determined an insertion variant, c read .102_103insA, in exon 1 of the CORIN gene. Evaluation of two independent cohorts demonstrated that the variant was preferentially present in hypertensive patients .
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