A man who has poor blood circulation pressure control A 60-year-old man has deteriorating blood circulation pressure control. What could be the cause? Should his antihypertensive medication be changed? Case scenario A 60-year-old man has been on a standard dose of a beta blocker for a long time. His last three readings, each three months apart, have been 140/90, 170/110 and 160/100 mmHg. Should I increase, add to, or alter his antihypertensive agent?Related StoriesRNA-based drugs provide many advantages over CRISPR/Cas9 gene editing systemResearchers determine tumor suppressor genes that drive subset of melanomasCHOP researchers delay symptoms, expand lifespan in animal model of Batten diseaseBy looking at entire genome sequences from 4,000 people and comparing this with data about their lipid levels, scientists spotted a link between levels of lipids called triglycerides and the presence of the APOC3 gene variant. The study suggests that people who have the rare change typically have lower levels of triglycerides, which is connected with reduced risk of cardiovascular disease. Two studies in the brand new England Journal of Medicine have lately explored the function of the genetic variant through the examination of APOC3 in a targeted strategy, and through coding and analysing only portion of the genome.